{"title":"Last Chance Supplements","description":"\u003cp\u003eFinal stock of our longevity and hair-health supplements from Capillus, Renue By Science and DoNotAge. Once they're gone, they're gone.\u003c\/p\u003e","products":[{"product_id":"capillus-hair-supplement","title":"Capillus Hair Supplement","description":"\u003cdiv class=\"product__description rte quick-add-hidden\"\u003e\n\u003cdiv class=\"m-0\"\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\n\u003cp\u003eMeet your new daily supplement to support thicker, fuller hair. The Capillus Hair Supplement is made with Cynatine HNS, which delivers bioavailable keratin that your body can absorb and utilize in your hair follicles to promote stronger and shinier looking hair.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eCynatine HNS, has been evaluated for its effects as a supplement for improving various aspects of hair and nails in a randomized, double-blind, placebo-controlled clinical trial.\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"noopener\" href=\"https:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/641723.pdf\" target=\"_blank\"\u003eDownload the clinical study here.\u003c\/a\u003e\u003cstrong\u003e\u003cspan class=\"h5 m-0\" style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"m-0 ps-5\"\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Capillus","offers":[{"title":"Default Title","offer_id":45329559748829,"sku":"CAPILLUS-CYNATINE","price":99.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/Cap_Supplements_Nutra-732849_576x_ff03e1b3-4c7f-4ad0-9218-81e40704594c.png?v=1717658015"},{"product_id":"capillus-dht-blocker","title":"Capillus DHT Blocker","description":"\u003cdiv class=\"rte\"\u003e\n\u003cp\u003eThe Capillus DHT Blocker is perfect for addressing hair loss and thinning at the crown, top, or frontal hairline. Packed with natural ingredients, it promotes optimal hair health, and controls hair loss. It works in both men and women, helping block the production of the DHT hormone, a major cause of thinning hair.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Capillus","offers":[{"title":"Default Title","offer_id":45329560174813,"sku":"CAPILLUS-DHT-BLOCKER","price":39.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/dht_0-642810_576x_216151f3-7c72-49f1-8f96-8ea3d0f0f9c9.png?v=1717658028"},{"product_id":"donotage-pure-fisetin","title":"DoNotAge Pure Fisetin","description":"\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cp\u003eOur Pure Fisetin provides 800mg of fisetin per serving. Fisetin is a senolytic that helps to get rid of the zombie cells that accumulate as we age. It supports healthy ageing.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!----\u003e","brand":"DoNotAge","offers":[{"title":"60 Capsules","offer_id":45385381871837,"sku":"PP0013","price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/DoNotAge_Fisetin.webp?v=1767255928"},{"product_id":"donotage-glycine-nac","title":"DoNotAge Glycine \u0026 NAC","description":"\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cp\u003eOne serving (two capsules) of our Glycine \u0026amp; NAC consists of 600mg of Glycine and 600mg of NAC.\u003c\/p\u003e\n\u003cp\u003eGlycine \u0026amp; NAC will increase autophagy and decrease your levels of methionine, which lessens the effect of age-related disease and helps to extend healthy lifespan.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!----\u003e","brand":"DoNotAge","offers":[{"title":"60 Capsules","offer_id":45387193057501,"sku":"PP0045","price":30.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/DoNotAge_Glycine_NAC.jpg?v=1767255613"},{"product_id":"donotage-sulforaboost","title":"DoNotAge SulforaBoost®","description":"\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cdiv class=\"product attribute overview\"\u003e\n\u003cdiv class=\"value\" itemprop=\"description\"\u003e\n\u003cp\u003eSulforaBoost® is an exclusive, all-natural product, derived from broccoli plants, and includes the active enzyme myrosinase. It increases the sulforaphane in your body and activates Nrf2.\u003c\/p\u003e\n\u003cp\u003eDoNotAge recommends taking 2-4 capsules daily.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!----\u003e","brand":"DoNotAge","offers":[{"title":"60 Capsules","offer_id":45387210621149,"sku":"PP0036","price":55.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/DoNotAge_SulforaBoost.jpg?v=1767255569"},{"product_id":"berberine-liposomal-90-ct","title":"Renue By Science Berberine (Liposomal) 90 Ct.","description":"\u003cdiv class=\"pd-body-text product__description rte quick-add-hidden\"\u003e\n\u003cdiv class=\"metafield-rich_text_field\"\u003e\n\u003cp\u003eBerberine is a natural compound shown to exert antioxidant and cardioprotective effects. LIPO Berberine is formulated to support glucose and lipid metabolism, heart health, and overall metabolic homeostasis.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737045917917,"sku":"656165997145","price":47.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-LIPO-Berberine-1_070df7a8-86d1-41cf-93ff-871fd5b61dcc.png?v=1727947257"},{"product_id":"coq10-liposomal-90-ct","title":"Renue By Science CoQ10 (Liposomal) 90 Ct.","description":"\u003cp\u003eLIPO CoQ10 features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect Coenzyme Q10 from digestive enzymes and carry it into the bloodstream for targeted systemic delivery.\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eCoQ10 is essential for the mitochondria to produce energy, maintain proper cellular function, provide support against oxidative stress, while offering potent anti-inflammatory properties.\u003c\/span\u003e\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737046081757,"sku":"656165996674","price":50.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-LIPO-CoQ10-1_d0cbddd2-98a4-453d-b94e-eeca8bc63c80.png?v=1727947265"},{"product_id":"oral-spray-with-nad-nmn-and-nr-liposomal","title":"Renue By Science Oral Spray with NAD⁺, NMN and NR (Liposomal)","description":"\u003cp\u003eIf you’re looking for a convenient on-the-go product, our oral spray is the perfect complement to your main NAD+ supplements.\u003c\/p\u003e\n\u003cp\u003eThis is best used for an instant NAD+ boost prior to working out, or during a long day, to help support healthy energy levels. Use this in conjunction with your main NAD+ supplement.\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737047064797,"sku":"656165996612","price":57.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-Liposomal-NADComplete-Oral-Spray-1-1_bfd07729-a240-4d01-953b-ab415f5dd02e.png?v=1727947303"},{"product_id":"quercetin-liposomal-90-ct","title":"Renue By Science Quercetin (Liposomal) 90 Ct.","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eQuercetin is a plant compound known for its diverse biological activity. LIPO Quercetin is designed to support healthy cellular activity, boost your immune system, and promote overall well-being.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eQuercetin is abundantly present in foods like apples, berries, onions, citrus fruits, green tea, and red wine. It is a flavonoid, a type of plant compound with diverse health effects, including:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant:\u003c\/strong\u003e Quercetin demonstrates the ability to scavenge free radicals and mitigate oxidative stress, thereby protecting cellular structures from damage \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmune system support:\u003c\/strong\u003e Quercetin may bolster immune defenses and promote a balanced immune response \u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHeart health:\u003c\/strong\u003e Quercetin promotes optimal blood vessel function and circulation \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eMaintaining Cellular Health Supports NAD+ Levels\u003c\/h3\u003e\n\u003cp\u003eThere is a growing interest in finding ways to restore NAD+ levels. Researchers have identified two main approaches to increasing NAD+ levels: boosting NAD+ levels through supplementation and reducing NAD+ consumption. It is suggested that a multi-target approach that combines both of these strategies is likely to be the most effective.\u003c\/p\u003e\n\u003cp\u003eStandard Quercetin has poor absorption and low bioavailability, with less than 10% making it to circulation after ingestion. (\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0924224421006506\"\u003e1\u003c\/a\u003e) To address this issue, LIPO Quercetin uses an advanced liposomal delivery system designed to improve the bioavailability, created for better absorption, and a slower release into the bloodstream.\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737047261405,"sku":"850055685178","price":46.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-LIPO-Quercetin-1_591177a7-1dd9-469a-87b1-f3db7704a931.png?v=1727947312"},{"product_id":"slc-enteric-nmn-nicotinamide-mononucleotide-delayed-release-250mg","title":"Renue By Science SLC Enteric NMN (Nicotinamide Mononucleotide, Delayed Release) 250mg","description":"\u003cp\u003eNMN is a natural compound known to boost NAD+ levels. SLC NMN is designed to maximize NMN uptake, restore methylation, and support the immune system.\u003c\/p\u003e\n\u003cp\u003eNAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. SLC NMN helps boost NAD+ production by providing NMN, a direct precursor to NAD+.\u003c\/p\u003e\n\u003cp\u003e“Together, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and\/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration.” (\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295222000405https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295222000405\"\u003e1\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003eNicotinamide mononucleotide (NMN) is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnergy production\u003c\/li\u003e\n\u003cli\u003eDNA repair\u003c\/li\u003e\n\u003cli\u003eRegulation of genes\u003c\/li\u003e\n\u003cli\u003eCellular health and vitality\u003c\/li\u003e\n\u003cli\u003eImmune function\u003c\/li\u003e\n\u003cli\u003eRegulation of the sleep-wake cycle\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNAD+ levels naturally decline with age, which research suggests is linked to the onset and progression of age-related diseases. This makes increasing NAD+ levels a promising therapeutic target.\u003c\/p\u003e\n\u003cp\u003eNMN serves as a direct precursor to NAD+, acting as a potent booster to elevate your NAD+ levels.\u003c\/p\u003e\n\u003cp\u003eSLC NMN is designed for enhanced absorption by promoting its interaction with the NMN transporter, Slc12a8.\u003c\/p\u003e\n\u003ch3\u003eThe NMN Transporter – Slc12a8\u003c\/h3\u003e\n\u003cp\u003eA 2019 \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530925\/\"\u003estudy\u003c\/a\u003e found some NMN can be transported directly through the cell membrane by the Slc12a8 Transporter and converted to NAD+ inside the small intestine.\u003c\/p\u003e\n\u003cp\u003eThe results from their study showed that older mice had increased levels of the transporter, leading to greater increases in NAD+ levels after NMN supplementation compared to young mice.\u003c\/p\u003e\n\u003cp\u003e“​​Therefore, increasing NMN availability or stimulating the function of the NMN transporter could effectively counteract age-associated NAD+ decline in the aged small intestine.”\u003c\/p\u003e\n\u003ch3\u003eProtecting NMN from Digestion by Bacteria is Key\u003c\/h3\u003e\n\u003cp\u003eHowever, another \u003ca href=\"https:\/\/assets.researchsquare.com\/files\/rs-87047\/v1_stamped.pdf\"\u003estudy\u003c\/a\u003e showed that most NMN is degraded by bacteria in your gut, limiting the amount of NAD+ that can be produced from standard NMN formulations.\u003c\/p\u003e\n\u003cp\u003eThese figures show the effect of gut bacteria on the intestinal levels of NMN (on the left) and NAD+ (on the right) after NMN supplementation.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGray bar:\u003c\/strong\u003e Normal, untreated mice\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eYellow bar:\u003c\/strong\u003e Mice receiving antibiotics\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlue bar:\u003c\/strong\u003e Mice receiving NMN\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRed bar:\u003c\/strong\u003e Mice receiving antibiotics and NMN\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe yellow and red bars represent mice given antibiotics to deplete their gut bacteria. Their levels are many times higher than mice with normal gut bacteria.\u003c\/p\u003e\n\u003ch3\u003eSLC NMN\u003c\/h3\u003e\n\u003cp\u003eSLC NMN uses a specially designed capsule that safeguards NMN from degradation by gut bacteria, ensuring that it arrives intact at the Slc12a8 transporter in your gut.\u003c\/p\u003e\n\u003cp\u003eThis unique NMN formulation features a number of key advantages to enhances absorption through Slc12a8 and promote your overall well-being:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAcid-resistant capsules:\u003c\/strong\u003e SLC NMN capsules are designed to protect the NMN through the stomach, providing more intact NMN in the small intestine for uptake by SLC12a8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrimethylglycine (TMG):\u003c\/strong\u003e TMG is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSodium Bicarbonate: \u003c\/strong\u003eSodium ions are needed for Slc12a8 to work properly, so we include them in our capsules along with NMN. This helps to ensure that more NMN is absorbed into your cells\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737047752925,"sku":"850055685055","price":67.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-SLC-NMN-200c-1_fcf0e5ef-2185-4926-be2d-befe1e9ea6f2.png?v=1727947326"},{"product_id":"slc-enteric-nmn-zinc-free-nicotinamide-mononucleotide-delayed-release-250mg","title":"Renue By Science SLC Enteric NMN Zinc Free (Nicotinamide Mononucleotide, Delayed Release) 250mg","description":"\u003cp\u003eNMN is a natural compound known to boost NAD+ levels. SLC NMN is designed to maximize NMN uptake, restore methylation, and support the immune system.\u003c\/p\u003e\n\u003cp\u003eNAD+ levels in the bloodstream are determined by a delicate balance between production and consumption. SLC NMN helps boost NAD+ production by providing NMN, a direct precursor to NAD+.\u003c\/p\u003e\n\u003cp\u003e“Together, this highlights that a multi-target strategy for NAD+ restoration such as the use of a precursor in combination with inhibitors and\/or activators acting at other key points in the NAD+ network may be the optimum approach to NAD+ restoration.” (\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295222000405https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295222000405\"\u003e1\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003eNicotinamide mononucleotide (NMN) is a naturally occurring molecule found in all cells. It is a precursor for NAD+, which is an important molecule for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEnergy production\u003c\/li\u003e\n\u003cli\u003eDNA repair\u003c\/li\u003e\n\u003cli\u003eRegulation of genes\u003c\/li\u003e\n\u003cli\u003eCellular health and vitality\u003c\/li\u003e\n\u003cli\u003eImmune function\u003c\/li\u003e\n\u003cli\u003eRegulation of the sleep-wake cycle\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eNAD+ levels naturally decline with age, which research suggests is linked to the onset and progression of age-related diseases. This makes increasing NAD+ levels a promising therapeutic target.\u003c\/p\u003e\n\u003cp\u003eNMN serves as a direct precursor to NAD+, acting as a potent booster to elevate your NAD+ levels.\u003c\/p\u003e\n\u003cp\u003eSLC NMN is designed for enhanced absorption by promoting its interaction with the NMN transporter, Slc12a8.\u003c\/p\u003e\n\u003ch3\u003eThe NMN Transporter – Slc12a8\u003c\/h3\u003e\n\u003cp\u003eA 2019 \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6530925\/\"\u003estudy\u003c\/a\u003e found some NMN can be transported directly through the cell membrane by the Slc12a8 Transporter and converted to NAD+ inside the small intestine.\u003c\/p\u003e\n\u003cp\u003eThe results from their study showed that older mice had increased levels of the transporter, leading to greater increases in NAD+ levels after NMN supplementation compared to young mice.\u003c\/p\u003e\n\u003cp\u003e“​​Therefore, increasing NMN availability or stimulating the function of the NMN transporter could effectively counteract age-associated NAD+ decline in the aged small intestine.”\u003c\/p\u003e\n\u003ch3\u003eProtecting NMN from Digestion by Bacteria is Key\u003c\/h3\u003e\n\u003cp\u003eHowever, another \u003ca href=\"https:\/\/assets.researchsquare.com\/files\/rs-87047\/v1_stamped.pdf\"\u003estudy\u003c\/a\u003e showed that most NMN is degraded by bacteria in your gut, limiting the amount of NAD+ that can be produced from standard NMN formulations.\u003c\/p\u003e\n\u003cp\u003eThese figures show the effect of gut bacteria on the intestinal levels of NMN (on the left) and NAD+ (on the right) after NMN supplementation.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGray bar:\u003c\/strong\u003e Normal, untreated mice\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eYellow bar:\u003c\/strong\u003e Mice receiving antibiotics\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlue bar:\u003c\/strong\u003e Mice receiving NMN\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRed bar:\u003c\/strong\u003e Mice receiving antibiotics and NMN\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThe yellow and red bars represent mice given antibiotics to deplete their gut bacteria. Their levels are many times higher than mice with normal gut bacteria.\u003c\/p\u003e\n\u003ch3\u003eSLC NMN\u003c\/h3\u003e\n\u003cp\u003eSLC NMN uses a specially designed capsule that safeguards NMN from degradation by gut bacteria, ensuring that it arrives intact at the Slc12a8 transporter in your gut.\u003c\/p\u003e\n\u003cp\u003eThis unique NMN formulation features a number of key advantages to enhances absorption through Slc12a8 and promote your overall well-being:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAcid-resistant capsules:\u003c\/strong\u003e SLC NMN capsules are designed to protect the NMN through the stomach, providing more intact NMN in the small intestine for uptake by SLC12a8\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTrimethylglycine (TMG):\u003c\/strong\u003e TMG is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity†\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSodium Bicarbonate: \u003c\/strong\u003eSodium ions are needed for Slc12a8 to work properly, so we include them in our capsules along with NMN. This helps to ensure that more NMN is absorbed into your cells\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737047785693,"sku":"850055685406","price":23.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-SLC-NMN-60c-1a.png?v=1727947329"},{"product_id":"tmg-methylation-essentials-120-ct","title":"Renue By Science TMG Methylation Essentials, 120 Ct.","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eTMG Methylation Essentials combines a crucial set of nutrients to support optimal methylation. The formulation is crafted to enable peak cellular function, DNA protection, and healthy aging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eTrimethylglycine (TMG), also known as Betaine, is a natural compound important for methylation, a vital cellular process that is essential for healthy aging and longevity.\u003c\/p\u003e\n\u003cp\u003eMethylation is a chemical process that happens in every cell of your body and it’s essential for:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMaking energy\u003c\/li\u003e\n\u003cli\u003eRepairing cells\u003c\/li\u003e\n\u003cli\u003eRegulating gene expression\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eNutrients to Support Methylation\u003c\/h3\u003e\n\u003cp\u003eTMG is a methyl donor, meaning that it provides more methyl groups to support methylation.† In addition to TMG, methylation pathways require other essential nutrients to function effectively, including Folate, Vitamin B6, Vitamin B12, and Zinc.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e“The changes in DNA methylation across a lifespan is a hallmark of aging.” (\u003ca href=\"https:\/\/academic.oup.com\/bfg\/article\/15\/6\/454\/2453164?login=false\"\u003e1\u003c\/a\u003e)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003ch3\u003eAging and Methylation Issues\u003c\/h3\u003e\n\u003cp\u003eResearch indicates that methylation pathways change as you age, contributing to the development of age-related health issues and impaired immune function.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\"Recent research efforts provided compelling evidence of genome-wide DNA methylation alterations in aging and age-related disease.\" \u003ca href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2020.00171\/full\"\u003e⑵\u003c\/a\u003e\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003eMethylation issues also contribute to high homocysteine levels, which is linked to a wide range of illnesses and serious medical conditions.†\u003c\/p\u003e\n\u003ch3\u003eNAD+ Precursors and Methylation Pathways\u003c\/h3\u003e\n\u003cp\u003eWhen taking standard (non-Liposomal) NMN or NR, the compounds are almost entirely degraded to NAM (Nicotinamide) before reaching tissues beyond the liver. In moderate amounts, NAM is beneficial for numerous health conditions. But, excessive NAM levels can be detrimental to your health.†\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e“High doses of NAM can cause genomic instability, reduce cellular methyl pools, and cause insulin resistance through methylated NAM.” (\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2212877821000351\"\u003e4\u003c\/a\u003e)\u003c\/p\u003e\n\u003c\/blockquote\u003e\n\u003cp\u003eIt has been shown that high doses of nicotinamide (NAM) lower plasma Betaine levels and decrease available methyl-groups in circulation.† (\u003ca href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0261561416301832\"\u003e5\u003c\/a\u003e) This is why NAD+ precursors are often supplemented with TMG and other compounds that support methylation pathways.†\u003c\/p\u003e\n\u003ch3\u003eAcid Resistant Enteric Capsules\u003c\/h3\u003e\n\u003cp\u003e​​Reaching the small intestines intact is critical to maximize uptake. Our Acid Resistant™ Enteric capsules have been engineered to make it through the harsh, acidic environment of the stomach without being degraded. They release their payload only when they reach the alkaline environment of the small intestine.\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737047916765,"sku":"850055685062","price":26.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-TMG-Methylation-Essentials-1-1_b7dd0ed0-e1f0-481a-8c23-309668e83d9f.png?v=1727947335"},{"product_id":"trans-resveratrol-liposomal-90-ct","title":"Renue By Science Trans-Resveratrol (Liposomal) 90 Ct.","description":"\u003cp\u003eResveratrol is a natural compound known for its anti-inflammatory and  antioxidant properties.†  LIPO Trans-Resveratrol is designed to support healthy aging, cellular function, and metabolic health.\u003c\/p\u003e\n\u003cp\u003eLIPO Trans-Resveratrol is also available in our combination product, Energizer AM.\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737048047837,"sku":"656165996384","price":39.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-LIPO-Trans-Resveratrol-1-1_32684483-2335-49f2-9c5f-19d0a06f4a20.png?v=1727947335"},{"product_id":"trans-resveratrol-powder-100-grams","title":"Renue By Science Trans-Resveratrol (Powder) 100 Grams","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eTrans-Resveratrol is a natural compound known for its anti-inflammatory and antioxidant properties. Our PURE Trans-Resveratrol™ 100-gram Crystalline Powder is designed to support healthy aging, cellular function, and metabolic health.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eResveratrol is a polyphenol, a type of plant compound, that has many potential health effects. It is found in a variety of plants, including grapes, apples, berries, and peanuts.\u003c\/p\u003e\n\u003cp\u003eThe potential health effects of Resveratrol arise from its scientifically recognized roles as an antioxidant and anti-inflammatory agent. These functions effectively target oxidative stress and inflammation—factors implicated in aging and age-related ailments. (\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8289612\/\"\u003e1\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003eResearch suggests that Resveratrol may help activate sirtuins, which are proteins that play an important role in regulating metabolism, inflammation, and aging. (\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5107309\/\"\u003e2\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003eResveratrol has been extensively researched for its potential in promoting longevity. Recent studies suggest it also supports heart health, glucose and fat metabolism, immune responses, and brain health. (\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7587336\/\"\u003e3\u003c\/a\u003e)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMany studies have shown the potential health benefits of Resveratrol: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLongevity: \u003c\/strong\u003eResveratrol’s anti-aging potential has been linked to its activity regulating cell death, improving mitochondrial function, reducing inflammation, and lowering oxidative stress.† (\u003ca href=\"https:\/\/www.hindawi.com\/journals\/omcl\/2021\/9932218\/\"\u003e4\u003c\/a\u003e) A \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3440975\/\"\u003emeta-analysis\u003c\/a\u003e of 19 studies showed that Resveratrol extended lifespan across 6 species: yeast, nematodes, mice, fruit flies, Mexican fruit flies, and turquoise killifish.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBone Integrity:\u003c\/strong\u003e Resveratrol supplementation improved bone density in the spine and femur neck, and lowered a marker of bone breakdown (C-terminal telopeptide type-1 collagen) by 7.24% in a 12-month \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7689937\/\"\u003eclinical trial\u003c\/a\u003e with postmenopausal women.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMetabolism:\u003c\/strong\u003e A \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27456934\/\"\u003epooled analysis\u003c\/a\u003e of 21 clinical studies found that Resveratrol supplementation significantly improved metabolic health in overweight and obese individuals, decreasing total cholesterol, systolic blood pressure, and fasting glucose.\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737048146141,"sku":"656165996681","price":82.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-PURE-TRANS-RESVERATROL-100gr-1-1_73425f7d-0349-4302-b3c2-3e7601587c7d.png?v=1727947338"},{"product_id":"vitamin-c-liposomal-120-ct","title":"Renue By Science Vitamin C (Liposomal) 120 Ct.","description":"\u003cp\u003eVitamin C is an essential nutrient known for its powerful antioxidant activity. LIPO Vitamin C is designed to enhance immune function, accelerate healing, and promote heart health.\u003c\/p\u003e\n\u003cp\u003eLIPO Vitamin C is also available in Shield.\u003c\/p\u003e","brand":"Renue By Science","offers":[{"title":"Default Title","offer_id":45737048244445,"sku":"656165996353","price":33.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0689\/5750\/3709\/files\/RENUE-LIPO-Vitamin-C-1-1_4d251ef3-15a7-4750-be93-8f71f43fd638.png?v=1727947343"}],"url":"https:\/\/biohackworld.com\/collections\/last-chance-supplements.oembed","provider":"Biohack World","version":"1.0","type":"link"}